Based on the popular video game, Milla Jovovich and Michelle Rodriguez star as the leaders of a commando team who must break into "the hive," a vast underground genetics laboratory operated by the powerful Umbrella Corporation. There, a deadly virus has been unleashed, killing the lab's personnel and resurrecting them as the evil Un-dead. The team has just three hours to shut down the lab's supercomputer and close the facility before the virus threatens to overrun the Earth.
The eerie and deserted ghost town of Silent Hill draws a young mother desperate to find a cure for her only child's illness. Unable to accept the doctor's diagnosis that her daughter should be permanently institutionalized for psychiatric care, Rose flees with her child, heading for the abandoned town in search of answers -- and ignoring the protests of her husband. It's soon clear this place is unlike anywhere she's ever been. It's smothered by fog, inhabited by a variety of strange beings and periodically overcome by a living "darkness" that literally transforms everything it touches. As Rose begins to learn the history of the strange town, she realizes that her daughter is just a pawn in a larger game.